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tert-butyl 7-(2-ethoxy-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate synthesis

12synthesis methods
-

Yield:243641-38-5 100%

Reaction Conditions:

with lithium diisopropyl amide in tetrahydrofuran at 0;

References:

Miller, William H.;Manley, Peter J.;Cousins, Russell D.;Erhard, Karl F.;Heerding, Dirk A.;Kwon, Chet;Ross, Stephen T.;Samanen, James M.;Takata, Dennis T.;Uzinskas, Irene N.;Yuan, Catherine C. K.;Haltiwanger, R. Curtis;Gress, Catherine J.;Lark, Michael W.;Hwang, Shing-Mei;James, Ian E.;Rieman, David J.;Willette, Robert N.;Yue, Tian-Li;Azzarano, Leonard M.;Salyers, Kevin L.;Smith, Brian R.;Ward, Keith W.;Johanson, Kyung O.;Huffman, William F. [Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,# 8,p. 1483 - 1486]