ChemicalBook CAS DataBase List 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester

5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester synthesis

5synthesis methods

Product Name:5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester
CAS Number:247237-43-0
Molecular formula:C21H24ClNO6S
Molecular Weight:453.94

2969-81-5 Synthesis

2969-81-5
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5-Chloro-2-[[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester

247237-38-3
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5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester

247237-43-0
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Yield:247237-43-0 726 g

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 120; for 2 h;

Steps:

4 Preparation of methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate

Reference Example 4
Preparation of methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate
Methyl 5-chloro-2-(N-p-taluenesulfonyl)aminobenzoate (585 gm) as obtained in reference example 3, ethyl-4-bromo butyrate (369.6 gm) and potassium carbonate (664 gm) in dimethylformamide (4400 ml) were added at room temperature.
The contents were heated to 120° C. and maintained for 2 hours.
The reaction mass was poured into water and filtered.
The solid obtained was dried to give 726 gm of methyl 5-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate.

References:

US2013/190490,2013,A1 Location in patent:Paragraph 0052; 0053

5202-89-1 Synthesis