ChemicalBook CAS DataBase List methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate

methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate synthesis

13synthesis methods

Product Name:methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate
CAS Number:255376-41-1
Molecular formula:C12H14O5
Molecular Weight:238.24

Benzeneacetic acid, 4-hydroxy-2-(methoxycarbonyl)-, methyl ester

21640-24-4
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77-78-1
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$22.00/25g

methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate

255376-41-1
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Yield:255376-41-1 98.3%

Reaction Conditions:

with potassium carbonate in acetone; for 4 h;Reflux;

Steps:

14.Procedures for the preparation of methyl5-methoxy-2-(2-methoxy-2-oxoethyl)benzoate(14)

9.0 g (0.039 mol) Compound 13 was dissolved in 100 ml dry acetone, 18 g (0.12 mol) anhydrous potassium carbonate and 4 ml(0.044 mol) dimethyl sulfate were added, refluxed for 4 h, cooled, filtered. Thefilter cake was washed with acetone, the filtrate was concentrated underreduced pressure to give a yellow oil 14 9.4 g,in yield of 98.3%.

References:

Zhao, Qian;Xu, Xi;Xie, Zhouling;Liu, Xiao;You, Qidong;Guo, Qinglong;Zhong, Yi;Li, Zhiyu [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 3,p. 1068 - 1072] Location in patent:supporting information

52962-25-1 Synthesis