3-(1,3-Dioxolan-2-yl)aniline synthesis
11synthesis methods
- Product Name:3-(1,3-Dioxolan-2-yl)aniline
- CAS Number:6398-87-4
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
Yield: 100%
Reaction Conditions:
with toluene-4-sulfonic acid in ethylene glycol;benzene
Steps:
3.3 (3-3)
A mixture of 3-nitrobenzaldehyde (100 g, 0.66 mole), ethylene glycol (49.3 g, 0.7 mole) and p-toluenesulfonic acid (0.8 g) and benzene (1 L) was heated at reflux with continuous removal of water via a Dean and Stark trap. After 4 hours, the mixture was cooled, filtered through a pad of neutral alumina and concentrated in vacuo to afford 2-(3-nitrophenyl)-1,3-dioxolane (130.4 g, 100%) as an amber oil used without further purification below. Step (b) 2-(3-Aminophenyl)-1,3-dioxolane
References:
Bristol-Myers Company US4701459, 1987, A