![](/CAS/GIF/70988-04-4.gif)
3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE synthesis
- Product Name:3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE
- CAS Number:70988-04-4
- Molecular formula:C11H11NO3
- Molecular Weight:205.21
![tert-Butyl cyanoacetate](/CAS/GIF/1116-98-9.gif)
1116-98-9
235 suppliers
$8.00/5g
![1-Bromo-3,5-dimethoxybenzene](/CAS/GIF/20469-65-2.gif)
20469-65-2
251 suppliers
$5.00/1g
![9-Methylfluorene-9-carbonyl chloride](/CAS/GIF/82102-37-2.gif)
82102-37-2
14 suppliers
$45.00/50mg
![3-(3',5'-DIMETHOXYPHENYL)-3-OXOPROPANENITRILE](/CAS/GIF/70988-04-4.gif)
70988-04-4
40 suppliers
inquiry
Yield:70988-04-4 77%
Reaction Conditions:
Stage #1: cyanoacetic acid tert-butyl ester;1-bromo-3,5-dimethoxybenzene;9-methyl-9H-fluorene-9-carbonyl chloridewith dichloro(1,5-cyclooctadiene)palladium(II);N-Methyldicyclohexylamine;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;magnesium chloride;tri tert-butylphosphoniumtetrafluoroborate in 1,4-dioxane at 100; for 18 h;Glovebox;Inert atmosphere;
Stage #2: with formic acid in 1,4-dioxane;Inert atmosphere;
References:
Jensen, Mikkel T.;Juhl, Martin;Nielsen, Dennis U.;Jacobsen, Mikkel F.;Lindhardt, Anders T.;Skrydstrup, Troels [Journal of Organic Chemistry,2016,vol. 81,# 4,p. 1358 - 1366]