ChemicalBook CAS DataBase List 3-Azaspiro[5.5]undecane-9-acetic acid methyl ester

3-Azaspiro[5.5]undecane-9-acetic acid methyl ester synthesis

4synthesis methods

Product Name:3-Azaspiro[5.5]undecane-9-acetic acid methyl ester
CAS Number:1017623-70-9
Molecular formula:C13H23NO2
Molecular Weight:225.33

1346229-41-1 Synthesis

3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester

1346229-41-1
13 suppliers
inquiry

3-Azaspiro[5.5]undecane-9-acetic acid methyl ester

1017623-70-9
12 suppliers
inquiry

Yield:-

Reaction Conditions:

with hydrogenchloride;methanol in 1,4-dioxane at 20; for 3 h;

Steps:

1.D Step D Methyl 2-(3-azaspiro[5.5]undecan-9-yl)acetate

To a round bottom flask was added the title compound from Example 1 Step C (20 g, 61.4 mmol) in MeOH (120ml), and then 4 M HCl in dioxane (48 mL) was added. The mixture was stirred at ambient temperature for 3 h. The solvent was removed under reduced pressure to afford an off-white solid as crude product. To the crude product was added saturated NaHCO₃ until basic. The water layer was extracted with DCM (2 x 300 niL), the organic layer was combined and washed with brine and dried over Na₂S0₄, filtered and dried down to afford the title compound that was used directly for next step.

References:

WO2014/59232,2014,A2 Location in patent:Page/Page column 40

3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, phenylMethyl ester

189333-18-4
22 suppliers
inquiry

1017623-70-9
12 suppliers
inquiry

References

138163-08-3 Synthesis

138163-08-3
192 suppliers
$6.00/1g

1017623-70-9
12 suppliers
inquiry

References

3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-(2-methoxy-2-oxoethylidene)-, phenylmethyl ester

1599478-96-2
0 suppliers
inquiry

1017623-70-9
12 suppliers
inquiry

References