3-bromo-2-chloroaniline synthesis
- Product Name:3-bromo-2-chloroaniline
- CAS Number:56131-46-5
- Molecular formula:C6H5BrClN
- Molecular Weight:206.47
3970-37-4
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56131-46-5
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$6.00/100mg
Yield:56131-46-5 100%
Reaction Conditions:
with iron;acetic acid in ethanol;water at 20; for 16 h;
Steps:
5 3-Bromo-2-chlorobenzenamine
To a mixture of l-bromo-2-chloro-3 -nitrobenzene (15.0 g, 63.60 mmol), HOAc (20 mL), EtOH (120 mL) and H20 (40 mL) at RT, iron powder (10.7 g, 190.70 mmol) was added in portions. The resulting mixture was stirred at RT for 16 h and then was neutralized with NaOH (5 N) solution. The mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (petroleum ether/ethyl acetate = 10: 1) to afford the desired product (14.0 g, 100% yield).
References:
ARAXES PHARMA LLC;LI, Liansheng;FENG, Jun;LONG, Yun, Oliver;LIU, Yuan;WU, Tao;REN, Pingda;LIU, Yi WO2017/15562, 2017, A1 Location in patent:Page/Page column 101
58534-94-4
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$10.00/1g
56131-46-5
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$6.00/100mg
59255-95-7
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$28.00/1g
56131-46-5
75 suppliers
$6.00/100mg
863870-72-8
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56131-46-5
75 suppliers
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863870-81-9
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56131-46-5
75 suppliers
$6.00/100mg