ChemicalBook CAS DataBase List 2-BROMO-6-NITROANILINE

2-BROMO-6-NITROANILINE synthesis

12synthesis methods

Product Name:2-BROMO-6-NITROANILINE
CAS Number:59255-95-7
Molecular formula:C6H5BrN2O2
Molecular Weight:217.02

58534-94-4 Synthesis

58534-94-4
191 suppliers
$10.00/1g

59255-95-7
130 suppliers
$28.00/1g

Yield:59255-95-7 91.3%

Reaction Conditions:

with ammonia in methanol at 100; for 16 h;Sealed tube;

Steps:

37
2-Bromo-6-nitroaniline A mixture of 1-bromo-2-fluoro-3-nitrobenzene (6.0 g, 27.27 mmol) and NH₃ in CH₃OH (7 M, 20 mL) was stirred in a sealed tube at 100 °C for 16 h. The solvent was removed and the residue was dissolved in H₂O, and then extracted with ethyl acetate. The organic layer was washed with brine, dried over Na₂SO₄ and concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate/petroleum ether = 1:100) to afford the product as a yellow solid (5.4 g, 91.3% yield).

References:

ARAXES PHARMA LLC;LI, Liansheng;FENG, Jun;WU, Tao;REN, Pingda;LIU, Yi;LIU, Yuan;LONG, Yun, Oliver WO2015/54572, 2015, A1 Location in patent:Page/Page column 271

FullText

88-74-4 Synthesis