![](/CAS/GIF/99548-54-6.gif)
3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER synthesis
- Product Name:3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER
- CAS Number:99548-54-6
- Molecular formula:C9H9BrO2
- Molecular Weight:229.07
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![3-Bromo-2-methylbenzoic acid](/CAS/GIF/76006-33-2.gif)
76006-33-2
315 suppliers
$10.00/5g
![3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/99548-54-6.gif)
99548-54-6
156 suppliers
$5.00/1g
Yield:99548-54-6 99%
Reaction Conditions:
with thionyl chloride at 70; for 1.5 h;
Steps:
112.1
To a mixture of 3-bromo-2-methylbenzoic acid (5.0 g, 23 mmol) in MeOH (80 mL) was added 50C12 (11.0 g, 93 mmol) at 20°C. The mixture was stirred for 1.5h at 70°C. Thevolatiles were removed and the residue was taken up by EtOAc (100 mL), which was washed sequentially with saturated NaHCO3 and brine (each 100 mL). The EtOAc layer was dried over Na2504, concentrated and the residue was purified by flash column chromatography to give methyl 3-bromo-2-methylbenzoate (5.3g, 99% yield) as a red solid.
References:
RQX PHARMACEUTICALS, INC.;GENENTECH, INC.;CHEN, Yongsheng;SMITH, Peter Andrew;ROBERTS, Tucker Curran;HIGUCHI, Robert I.;PARASELLI, Prasuna;KOEHLER, Michael F. T.;SCHWARZ, Jacob Bradley;CRAWFORD, James John;LY, Cuong Q.;HANAN, Emily J.;HU, Huiyong;YU, Zhiyong WO2017/84630, 2017, A1 Location in patent:Paragraph 00545
![3-Bromo-2-methylbenzoic acid](/CAS/GIF/76006-33-2.gif)
76006-33-2
315 suppliers
$10.00/5g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/99548-54-6.gif)
99548-54-6
156 suppliers
$5.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![3-BROMO-2-METHYL BENZOYL CHLORIDE](/CAS/GIF/21900-48-1.gif)
21900-48-1
31 suppliers
$60.00/100mg
![3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/99548-54-6.gif)
99548-54-6
156 suppliers
$5.00/1g
![3-Bromo-2-methylbenzoic acid](/CAS/GIF/76006-33-2.gif)
76006-33-2
315 suppliers
$10.00/5g
![5-Bromo-2-methylbenzoic acid](/CAS/GIF/79669-49-1.gif)
79669-49-1
437 suppliers
$5.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/99548-54-6.gif)
99548-54-6
156 suppliers
$5.00/1g
![methyl 5-bromo-2-methyl-benzoate](/CAS/GIF/79669-50-4.gif)
79669-50-4
183 suppliers
$12.00/5g
![3-Bromo-2-methylbenzoic acid](/CAS/GIF/76006-33-2.gif)
76006-33-2
315 suppliers
$10.00/5g
![3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER](/CAS/GIF/99548-54-6.gif)
99548-54-6
156 suppliers
$5.00/1g