ChemicalBook CAS DataBase List BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER

BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER synthesis

7synthesis methods

Product Name:BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER
CAS Number:99548-55-7
Molecular formula:C9H9BrO2
Molecular Weight:229.07

68837-59-2 Synthesis

68837-59-2
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74-88-4
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BENZOIC ACID,4-BROMO-2-METHYL-,METHYL ESTER

99548-55-7
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Yield:99548-55-7 100%

Reaction Conditions:

with sodium hydrogencarbonate in N,N-dimethyl-formamide at 80;

Steps:

5.5.76.1
5.76 l-(3-CHIX)RO-4-METHYI_^PHENYLV3-r2-f2.6-DIOXO-PIPERrom- 3-YU-I-OXO-Z^-DIHYDRO-IH-ISOINDOL-S-YLMETHYLI-TJREA Step 1: A mechanically stirred mixture of 4-bromo-2-methyl-benzoic acid (100 g, 465 mmol), iodomethane (95 g, 670 mmol) and sodium bicarbonate (1 12 g, 1340 mmoi) in DMF (325 mL) was heated at 80 ⁰C overnight. The reaction mixture was cooled to room temperature and partitioned between water (1500 mL) and 4: 1 hexanes:ethyl acetate (1500 mL). The organic layer was washed with water and dried (Na₂SO₄). The solvent was removed under vacuum to give HO g of 4-bromo-2-methyl-benzoic acid methyl ester as an oil, in 100% yield; ¹H NMR δ 2.51 (s, 3H), 3.84 (s, 3H), 7.40-7.78 (m, 3H).

References:

CELGENE CORPORATION WO2008/27542, 2008, A2 Location in patent:Page/Page column 89-90

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68837-59-2 Synthesis

68837-59-2
331 suppliers
$5.00/1g