3-Bromo-6-mercaptopyridine synthesis
- Product Name:3-Bromo-6-mercaptopyridine
- CAS Number:56673-34-8
- Molecular formula:C5H4BrNS
- Molecular Weight:190.06
13466-38-1
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$6.00/5g
56673-34-8
70 suppliers
$15.00/250mg
Yield: 96%
Reaction Conditions:
with Lawessons reagent in toluene for 1 h;Inert atmosphere;Reflux;
Steps:
Lawesson's reagent (available from Aldrich Chemical Company, Inc., 1001 West Saint Paul Avenue, Milwaukee, Wis. 53233, USA; 2.32 g, 5.74 mmol) was added in portions to a suspension of 5-bromo-2(1H)-pyridone (available from Aldrich Chemical Company, Inc., 1001 West Saint Paul Avenue, Milwaukee, Wis. 53233, USA; 2 g, 11.5 mmol) in dry toluene (50 mL) under nitrogen. The reaction mixture was heated at reflux for 1 h and then cooled to room temperature. The product that precipitated on cooling was collected by filtration and dried under high vacuum to give 5-bromo-pyridine-2-thiol (2.1 g, 96%), which was used directly in the next step without further purification.
References:
Firooznia, Fariborz;Gillespie, Paul;Lin, Tai-An;So, Sung-Sau US2012/309796, 2012, A1 Location in patent:Page/Page column 25
13466-38-1
385 suppliers
$6.00/5g
56673-34-8
70 suppliers
$15.00/250mg
53939-30-3
457 suppliers
$5.00/1g
56673-34-8
70 suppliers
$15.00/250mg
766-11-0
440 suppliers
$6.00/5g
56673-34-8
70 suppliers
$15.00/250mg