3-(CHLOROMETHYL)-5-FLUOROPYRIDINE synthesis
- Product Name:3-(CHLOROMETHYL)-5-FLUOROPYRIDINE
- CAS Number:39891-37-7
- Molecular formula:C6H5ClFN
- Molecular Weight:145.56
22620-32-2
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Yield:39891-37-7 166 mg
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 2 h;
Steps:
76.2 Step 2 3 -(chloromethyl -5 -fluoropyridine
Step 2 3 -(chloromethyl -5 -fluoropyridine To a solution of (5-fluoropyridin-3-yl)methanol (0.19 g, 1.50 mmol) in DCM (5 mL) was added thionyl chloride (0.19 ml, 2.6 mmol) at 0 °C. The reaction was stirred at room temperature for 2 h. The reaction was concentrated and the residue was dried in vacuo to yield 3-(chloromethyl)-5- fiuoropyridine (166 mg) which was used without characterization.
References:
WO2014/143799,2014,A2 Location in patent:Page/Page column 429; 430
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