3-CYCLOPROPYLPYRIDINE-2-CARBONITRILE synthesis

5synthesis methods

Product Name:3-CYCLOPROPYLPYRIDINE-2-CARBONITRILE
CAS Number:878805-22-2
Molecular formula:C9H8N2
Molecular Weight:144.17

1065010-87-8 Synthesis

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55758-02-6 Synthesis

55758-02-6
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878805-22-2
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Yield:878805-22-2 320 mg

Reaction Conditions:

with palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride;Cs₂CO₃ in lithium hydroxide monohydrate;toluene at 110; for 14 h;Inert atmosphere;

Steps:

506.1 Step-1. 3-cyclopropylpyridine-2-carbonitrile

Cyclopropyltrifluoro-V-borane potassium (646.9 mg, 4.37 mmol), Pd(dppf)Ch (319.9 mg, 0.44 mmol) and CS2CO3 (1424.3 mg, 4.37 mmol) were added to a stirred solution of 3- bromopyridine-2-carbonitrile (400.0 mg, 2.19 mmol) in toluene (5.00 mL) and H₂O (0.50 mL). The resulting mixture was stirred at 110 °C for 14 h under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography eluting with DCM/MeOH (20/1 v/v) to obtain the title compound (320.0 mg) as a solid. LCMS (ESI): 145.00 [M+H]⁺.

References:

WO2022/99144,2022,A1 Location in patent:Paragraph 4713-4715

55758-02-6 Synthesis

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411235-57-9 Synthesis