4-(1,1-difluoroethyl)benzaldehyde synthesis

6synthesis methods

Product Name:4-(1,1-difluoroethyl)benzaldehyde
CAS Number:55805-22-6
Molecular formula:C9H8F2O
Molecular Weight:170.16

55805-25-9 Synthesis

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55805-22-6
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Yield:55805-22-6 81%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane at 20; for 1 h;Inert atmosphere;

Steps:

1.3 Step three: Preparation of 4- (1,1-difluoroethyl) benzaldehyde

4- (1,1-Difluoroethyl) benzyl alcohol (1.93 g, 11.21 mmol) was dissolved in 50 mL of dry CH 2 Cl 2,PCC (pyridinium chlorochromate) (3.63 g, 16.82 mmol, 1.5 eq) was added,N2 protection,Stirred at room temperature for 1 h,TLC trace detection until the reaction is complete,Saturated aqueous NaCl solution was added,Washed with saturated aqueous NaHCO3 to a colorless,Extracted with ethyl acetate,Dried over anhydrous Na2SO4,filter,Concentrated and dried to give a white solid 1.55g,Yield 81%.

References:

CN107311846,2017,A Location in patent:Paragraph 0023; 0028; 0029