![](/CAS2/GIF/1151802-23-1.gif)
4-bromo-1-cyclopropyl-1H-pyrazole synthesis
- Product Name:4-bromo-1-cyclopropyl-1H-pyrazole
- CAS Number:1151802-23-1
- Molecular formula:C6H7BrN2
- Molecular Weight:187.04
![4-Bromopyrazole](/CAS/GIF/2075-45-8.gif)
2075-45-8
396 suppliers
$5.00/5g
![Cyclopropyl bromide](/CAS/GIF/4333-56-6.gif)
4333-56-6
377 suppliers
$6.00/5g
![4-bromo-1-cyclopropyl-1H-pyrazole](/CAS2/GIF/1151802-23-1.gif)
1151802-23-1
91 suppliers
$24.00/100mg
Yield: 68%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 180; for 1.5 h;Microwave irradiation;
Steps:
A30.1 Step 1 : 4-Bromo- 1 -cyc
Step 1 : 4-Bromo- 1 -cyc A mixture of 4-bromo-lH-pyrrazole (1.0 g, 6.8 mmol), bromo cyclopropane (1.3 g, 10.7 mmol), cesium carbonate (3.5 g. 10.7 mmol), and DMF (6 mL) in a 30 mL microwave vial is heated to 180 °C under radiation for 1.5 hr. After cooled to room temperature, the reaction mixture is filtered. The filtrate is concentrated and the residue is purified on a silica gel flash chromatography with ethyl acetate/petroleum ether (1 :5) to get a brown liquid (0.87 g, 68% yield). (MS: [M+l] 259)
References:
Location in patent:Page/Page column 14
![4-Bromopyrazole](/CAS/GIF/2075-45-8.gif)
2075-45-8
396 suppliers
$5.00/5g
![Cyclopropylboronic acid](/CAS/GIF/411235-57-9.gif)
411235-57-9
426 suppliers
$6.00/1g
![4-bromo-1-cyclopropyl-1H-pyrazole](/CAS2/GIF/1151802-23-1.gif)
1151802-23-1
91 suppliers
$24.00/100mg
![1-Cyclopropyl-1H-pyrazole](/CAS/20150408/GIF/1151814-36-6.gif)
1151814-36-6
48 suppliers
$108.00/100mg
![4-bromo-1-cyclopropyl-1H-pyrazole](/CAS2/GIF/1151802-23-1.gif)
1151802-23-1
91 suppliers
$24.00/100mg