![](/CAS/GIF/70441-63-3.gif)
4-FLUORO-N-ISOPROPYLANILINE synthesis
- Product Name:4-FLUORO-N-ISOPROPYLANILINE
- CAS Number:70441-63-3
- Molecular formula:C9H12FN
- Molecular Weight:153.2
![4-Fluoronitrobenzene](/CAS/GIF/350-46-9.gif)
350-46-9
512 suppliers
$10.60/1gm:
![4-FLUORO-N-ISOPROPYLANILINE](/CAS/GIF/70441-63-3.gif)
70441-63-3
136 suppliers
$34.00/250mg
Yield:70441-63-3 97%
Reaction Conditions:
Pt on charcoal in water;acetone;toluene
Steps:
1.a Preparation of 4-fluoro-N-isopropylaniline
Example 1a Preparation of 4-fluoro-N-isopropylaniline 520 parts of toluene, 423 parts (3 mol) of 4-fluoronitrobenzene, 192 parts (3.3 mol) of acetone and 8 parts of catalyst (5% Pt on charcoal, water-moist, water content 50%) are placed in a hydrogenation autoclave. After the gas space has been flushed three times with each of nitrogen and hydrogen, the mixture is heated to from 80°=0 to 85° C. with stirring and reduced at a hydrogen pressure of from 0.2 to 1.0 MPa. When after about 2 hours the uptake of hydrogen falls sharply, the pressure is raised to 2.0 MPa and stirring is continued at 85° C for 30 minutes until there is no longer any drop in pressure. The batch is cooled to 60° C., the autoclave is let down and flushed with nitrogen, and the catalyst is filtered off on a pressure filter at from 50° to 60° C. The aqueous phase is separated off from the filtrate and toluene is distilled off until the water content of the solution is <0.02%. The solution is processed further in accordance with Example 2. Alternatively, the solution can be worked up by distillation and the product isolated. Yield 97-98%; purity by GC: ≥99.2%; boiling point: 91° to 92° C./10 torr.
References:
Hoechst Aktiengesellschaft US5616799, 1997, A
![4-Fluoronitrobenzene](/CAS/GIF/350-46-9.gif)
350-46-9
512 suppliers
$10.60/1gm:
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77-76-9
384 suppliers
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![4-FLUORO-N-ISOPROPYLANILINE](/CAS/GIF/70441-63-3.gif)
70441-63-3
136 suppliers
$34.00/250mg
![4-Fluoronitrobenzene](/CAS/GIF/350-46-9.gif)
350-46-9
512 suppliers
$10.60/1gm:
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67-64-1
6 suppliers
$17.30/10ml
![4-FLUORO-N-ISOPROPYLANILINE](/CAS/GIF/70441-63-3.gif)
70441-63-3
136 suppliers
$34.00/250mg
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70441-63-3
136 suppliers
$34.00/250mg
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403 suppliers
$5.00/5 g
![4-FLUORO-N-ISOPROPYLANILINE](/CAS/GIF/70441-63-3.gif)
70441-63-3
136 suppliers
$34.00/250mg