4-Pyridineacetonitrile,2,6-dimethyl-(9CI) synthesis

6synthesis methods

Product Name:4-Pyridineacetonitrile,2,6-dimethyl-(9CI)
CAS Number:130138-46-4
Molecular formula:C9H10N2
Molecular Weight:146.19

75523-42-1 Synthesis

75523-42-1
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$1320.00/5g

143-33-9 Synthesis

143-33-9
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$10.00/1g

4-Pyridineacetonitrile,2,6-dimethyl-(9CI)

130138-46-4
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Yield:130138-46-4 80%

Reaction Conditions:

in dimethyl sulfoxide at 0 - 20; for 3 h;

Steps:

196.b

b) 4-(2-Methylpyridyl)acetonitrile; To 10 mL of DMSO solution containing 1.7 g of sodium cyanide, 3 mL of DMSO solution containing 2.46 g of 4-chloromethyl-2-methylpyridine was added under cooling with ice, and stirred at room temperature for 3 hours. After addition of water, the reaction solution was extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation to provide 1.86 g (yield: 80%) of the title compound which was a reddish brown, oily substance. ¹H-NMR(CDCl₃)δ:8.43(d,J=5.0Hz,1H),7.22(s,1H), 7.16(d,J=5.0Hz,1H),4.08(s,2H),2.47(s,3H) Mass,m/e:132(M⁺,base)

References:

EP2036905,2009,A1 Location in patent:Page/Page column 49