![](/CAS/GIF/158063-66-2.gif)
4-(Trifluoromethyl)nicotinic acid synthesis
- Product Name:4-(Trifluoromethyl)nicotinic acid
- CAS Number:158063-66-2
- Molecular formula:C7H4F3NO2
- Molecular Weight:191.11
![4-(Trifluoromethyl)nicotinonitrile](/CAS/GIF/13600-43-6.gif)
13600-43-6
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$32.00/1g
![4-(Trifluoromethyl)nicotinic acid](/CAS/GIF/158063-66-2.gif)
158063-66-2
350 suppliers
$5.00/250mg
Yield:158063-66-2 98.3%
Reaction Conditions:
with water;sodium hydroxide at 100;Temperature;
Steps:
9 Example 9: Preparation of 4-trifluoromethylnicotinic acid.
In a 1000 mL sealed four-neck reaction flask, add 150 g of sodium hydroxide and 500 mL of water, stir well,Further, 172.1 g of 4-trifluoromethyl cigarette obtained in the above Example 4 was added, and the mixture was stirred and controlled at a temperature of 100 ° C, and the solid was dissolved and turned into a pale yellow clear solution, then the stirring was stopped, the pH was adjusted with hydrochloric acid, and the mixture was cooled and filtered.The white solid was 187.9 g of 4-trifluoromethylnicotinic acid in a yield of 98.3%.
References:
Zhejiang University Of Technology Shangyu Institute Co., Ltd.;Fang Biao;Ke Junliang;Xu Meng CN109467532, 2019, A Location in patent:Paragraph 0034-0039
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158063-66-2
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![4-(Trifluoromethyl)nicotinic acid](/CAS/GIF/158063-66-2.gif)
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![4-(Trifluoromethyl)nicotinic acid](/CAS/GIF/158063-66-2.gif)
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590371-81-6
109 suppliers
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![4-(Trifluoromethyl)nicotinic acid](/CAS/GIF/158063-66-2.gif)
158063-66-2
350 suppliers
$5.00/250mg