ChemicalBook CAS DataBase List N-(benzylsulfamoyl)-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine

N-(benzylsulfamoyl)-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine synthesis

11synthesis methods

Product Name:N-(benzylsulfamoyl)-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine
CAS Number:441796-09-4
Molecular formula:C23H20Br2N6O4S
Molecular Weight:636.3157

2-[6-(benzylsulfamoylamino)-5-(4-bromophenyl)pyrimidin-4-yl]oxyethanol

441796-08-3
3 suppliers
inquiry

32779-36-5 Synthesis

32779-36-5
632 suppliers
$5.00/5g

N-(benzylsulfamoyl)-5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-amine

441796-09-4
8 suppliers
inquiry

Yield:441796-09-4 76%

Reaction Conditions:

Stage #1: N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamidewith sodium hydride in tetrahydrofuran;mineral oil; for 0.166667 h;
Stage #2: 5-Bromo-2-chloropyrimidine in tetrahydrofuran;N,N-dimethyl-formamide;mineral oil at 20; for 0.333333 h;

References:

Bolli, Martin H.;Boss, Christoph;Binkert, Christoph;Buchmann, Stephan;Bur, Daniel;Hess, Patrick;Iglarz, Marc;Meyer, Solange;Rein, Josiane;Rey, Markus;Treiber, Alexander;Clozel, Martine;Fischli, Walter;Weller, Thomas [Journal of Medicinal Chemistry,2012,vol. 55,# 17,p. 7849 - 7861] Location in patent:supporting information

146533-41-7 Synthesis