ChemicalBook CAS DataBase List 1,3-DiMethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-5-carboxylic Acid

1,3-DiMethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-5-carboxylic Acid synthesis

11synthesis methods

Product Name:1,3-DiMethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-5-carboxylic Acid
CAS Number:4869-45-8
Molecular formula:C7H8N2O4
Molecular Weight:184.15

88468-97-7 Synthesis

Methyl 1,3-diMethyl-2,4-dioxopyriMidine-5-carboxylate

88468-97-7
16 suppliers
$315.00/250mg

1,3-DiMethyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-5-carboxylic Acid

4869-45-8
49 suppliers
$20.00/100mg

Yield:4869-45-8 300 mg

Reaction Conditions:

with water;sodium hydroxide in methanol at 20; for 3 h;

Steps:

1.B (B) 1, 3-dimethyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylic acid

In a reaction flask, methyl 1, 3-dimethyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate (500 mg, 2.5 mmol) was dissolved in methanol (6 ml) and water (1.5 ml) , and NaOH (200 mg, 5 mmol) was added, the reaction solution was reacted at room temperature for 3 hours. The reaction solution was revolved to remove methanol, and neutralized with 1N hydrochloric acid to pH = 3, the solid was precipitated, filtered, dried, to obtain 300 mg of a white solid. MS (m/z) : 185 [M+H]⁺.

References:

WO2021/197276,2021,A1 Location in patent:Page/Page column 56