Methyl 1,3-diMethyl-2,4-dioxopyriMidine-5-carboxylate synthesis
- Product Name:Methyl 1,3-diMethyl-2,4-dioxopyriMidine-5-carboxylate
- CAS Number:88468-97-7
- Molecular formula:C8H10N2O4
- Molecular Weight:198.18
23945-44-0
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Yield:88468-97-7 0.8 g
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 60; for 16 h;
Steps:
1.A (A) methyl 1, 3-dimethyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate
In a reaction flask, uracil-5-carboxylic acid (1 g, 6.4 mmol) was dissolved in DMF (15 ml) , and Cs2CO3(12.5 g, 38.4 mmol) and CH3I (4.6 g, 32 mmol) were successively added, the reaction solution was reacted at 60 for 16 hours. Water was added to the reaction solution, and the reaction solution was extracted with ethyl acetate, washed with saturated brine, and dried with anhydrous sodium sulfate. The reactant was concentrated to obtain 0.8 g of a khaki solid. MS (m/z) : 199 [M+H]+.
References:
WO2021/197276,2021,A1 Location in patent:Page/Page column 56
23945-44-0
275 suppliers
$5.00/250mg
88468-97-7
16 suppliers
$315.00/250mg
4869-45-8
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88468-97-7
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$315.00/250mg
67-56-1
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88468-97-7
16 suppliers
$315.00/250mg