ChemicalBook CAS DataBase List 5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE synthesis

5synthesis methods

Product Name:5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE
CAS Number:96799-04-1
Molecular formula:C10H11N3O
Molecular Weight:189.21

3672-47-7
151 suppliers
$16.00/500mg

5-(3-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE

96799-04-1
70 suppliers
$45.00/1g

Yield:96799-04-1 95%

Reaction Conditions:

with toluene-4-sulfonic acid;hydrazine hydrate in ethanol at 78; for 2 h;

Steps:

4.1.2. Synthesis of key intermediates 10a-c

General procedure: To a solution of 9 (5 mmol) and p-toluenesulfonic acid (TsOH,0.1 mmol) in ethanolwas added 80% hydrazine hydrate dropwise at78 °C. On completion of the reaction (TLC check), the solvent wasremoved under reduced pressure and the crude product was purifiedby silica gel column chromatography to afford intermediates10a-c as white solid in excellent yields.

References:

Zhai, Min'an;Liu, Shiyuan;Gao, Meiqi;Wang, Long;Sun, Jun;Du, Jianan;Guan, Qi;Bao, Kai;Zuo, Daiying;Wu, Yingliang;Zhang, Weige [European Journal of Medicinal Chemistry,2019,vol. 168,p. 426 - 435]

21667-60-7 Synthesis