![](/CAS/GIF/1463-10-1.gif)
5-Methyluridine synthesis
- Product Name:5-Methyluridine
- CAS Number:1463-10-1
- Molecular formula:C10H14N2O6
- Molecular Weight:258.23
![Uridine, 5-methyl-, 2',3',5'-tribenzoate](/CAS/20180529/GIF/3180-76-5.gif)
3180-76-5
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![Ethyl benzoate](/CAS/GIF/93-89-0.gif)
93-89-0
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$13.00/100g
![Benzamide](/CAS/GIF/55-21-0.gif)
55-21-0
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$5.00/5G
![5-Methyluridine](/CAS/GIF/1463-10-1.gif)
1463-10-1
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$5.00/250mg
Yield:1463-10-1 95%
Reaction Conditions:
with ammonia in ethanol at 20;
Steps:
6 Example 6; 1-(β-L-Ribofuranosyl)thymine (4, B=thymine)
Compound 3 (B=thymine, R2=Bz) prepared above (28 g, 0.05 mol) in 560 mL of ethanolic ammonia (saturated at 0° C.) is kept standing overnight at room temperature. The solution is concentrated in vacuo, and the residue is triturated with diethyl ether (200 mL×2) to remove ethyl benzoate and benzamide. The insoluble residue is crystallized from ethanol to give 13.0 g (95%) of 4 (B=thymine), mp 183-185° C. The 1H-NMR spectrum of this sample is identical to that of the D-counterpart. (Fox, J. J.; Yung, N.; Davoll, J.; Brown, G. B. J. Am. Chem. Soc. 1956, 78, 2117.)
References:
US2005/90660,2005,A1 Location in patent:Page/Page column 36
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![5-Methyluridine](/CAS/GIF/1463-10-1.gif)
1463-10-1
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![1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE](/CAS/GIF/144490-03-9.gif)
144490-03-9
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$30.00/1g
![BIS(O-TRIMETHYLSILYL)THYMINE](/CAS/GIF/7288-28-0.gif)
7288-28-0
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$60.00/250mg
![5-Methyluridine](/CAS/GIF/1463-10-1.gif)
1463-10-1
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4336-39-4
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![5-Methyluridine](/CAS/GIF/1463-10-1.gif)
1463-10-1
381 suppliers
$5.00/250mg