5-OXO-5-(2-PYRIDYL)VALERIC ACID synthesis
2synthesis methods
- Product Name:5-OXO-5-(2-PYRIDYL)VALERIC ACID
- CAS Number:13672-84-9
- Molecular formula:C10H11NO3
- Molecular Weight:193.2
Yield:13672-84-9 70%
Reaction Conditions:
Stage #1: 2-bromo-pyridinewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.5 h;
Stage #2: glutaric anhydride, in tetrahydrofuran;hexane at -78 - 20;
References:
Uyanik, Muhammet;Yasui, Takeshi;Ishihara, Kazuaki [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 14,p. 3848 - 3851] Location in patent:supporting information; experimental part
