5-OXO-5-(3-PYRIDYL)VALERIC ACID synthesis
- Product Name:5-OXO-5-(3-PYRIDYL)VALERIC ACID
- CAS Number:22971-46-6
- Molecular formula:C10H11NO3
- Molecular Weight:193.2
93-60-7
457 suppliers
$8.00/25g
818-38-2
195 suppliers
$36.39/25g
22971-46-6
13 suppliers
$283.00/1g
Yield:-
Reaction Conditions:
Stage #1: Diethyl glutaratewith sodium hydride in tetrahydrofuran at 0;
Stage #2: Methyl nicotinate in tetrahydrofuran at 25;Reagent/catalyst;
Steps:
Step S1:
48 g (2 mol, 2 eq) of NaH and 282.3 g (1.5 mol, 1.5 eq) of diethyl glutarate were dissolved in 4 L of tetrahydrofuran at 0° C., a reaction was performed at 0° C. for 30 min, 137.1 g (1 mol) of methyl nicotinate was added, and a condensation reaction was performed at 25° C. and monitored by TCL until the end of the reaction to obtain a mixture containing 5-carbonyl-5-(pyridin-3-yl)pentanoic acid.
References:
US2023/9969,2023,A1 Location in patent:Paragraph 0069; 0077
614-18-6
462 suppliers
$5.00/10g
818-38-2
195 suppliers
$36.39/25g
22971-46-6
13 suppliers
$283.00/1g
93-60-7
457 suppliers
$8.00/25g
1119-40-0
323 suppliers
$5.00/10g
22971-46-6
13 suppliers
$283.00/1g