2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester synthesis

7synthesis methods

Product Name:2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester
CAS Number:54032-88-1
Molecular formula:C14H15NO3S
Molecular Weight:277.34

2362-64-3
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609-15-4 Synthesis

609-15-4
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2-(4-Methoxy-phenyl)-4-methyl-thiazole-5-carboxylicacidethylester

54032-88-1
26 suppliers
$108.75/1g

Yield:54032-88-1 92%

Reaction Conditions:

in ethanol at 70; for 6 h;

Steps:

1 Ethyl 2-(4-methoxyphenyl)-4-methylthiazole-5-carboxylate (T7):

Add 4-methoxybenzamide (152.2 mg, 1 mmol) to a 25 mL round bottom flask.Lawesen reagent (485.4mg, 1.2mmol) and THF (20mL) were reacted at room temperature for 4h, then the Lawson reagent and solvent were removed, and the intermediate thiobenzamide was obtained by column chromatography.Then, it was refluxed with ethyl 2-chloroacetoacetate (329.2 mg, 2 mmol) in a solvent ethanol (20 mL) at 70 ° C for 6 hours. After completion of the reaction, the solvent was removed and purified by column chromatography to give Compound T7. Yield 92%, white solid, unfolded system PE/EA 10:1 (Rf = 0.5, PE / EA = 3:1)

References:

CN109810071,2019,A Location in patent:Paragraph 0061; 0072; 0073

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638-07-3 Synthesis