![](/CAS/GIF/5952-93-2.gif)
1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
- CAS Number:5952-93-2
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
![METHYL 1H-PYRAZOLE-4-CARBOXYLATE](/CAS/GIF/51105-90-9.gif)
51105-90-9
114 suppliers
$9.00/100mg
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/5952-93-2.gif)
5952-93-2
65 suppliers
$60.00/100mg
Yield:5952-93-2 90%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
131.1 first step 1-methyl-1H-pyrazole-4-carboxylate methyl ester
Methyl pyrazole-4-carboxylate 131a (5 g, 39.65 mmol) was dissolved in N,N-dimethylformamide (50 mL),Potassium carbonate (10.96 g, 79.29 mmol) and methyl iodide (6.19 g, 43.61 mmol) were sequentially added, and the reaction was stirred at room temperature for 1 hour.Water (50 mL) was added, extracted with ethyl acetate (50 mL×3), the organic phases were combined, washed successively with water (50 mL) and saturated sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure.The obtained residue was further separated and purified by silica gel column chromatography (eluent: system A),1-Methyl-1H-pyrazole-4-carboxylate methyl ester 131b (5.04 g) was obtained, yield: 90%.
References:
WO2022/57849,2022,A1 Location in patent:Page/Page column 166-167
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/5952-92-1.gif)
5952-92-1
232 suppliers
$5.00/250mg
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
207 suppliers
$33.00/5g
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/5952-93-2.gif)
5952-93-2
65 suppliers
$60.00/100mg
![4-Iodo-1-methyl-1H-pyrazole](/CAS/GIF/39806-90-1.gif)
39806-90-1
223 suppliers
$9.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$9.00/25ml
201230-82-2
1 suppliers
inquiry
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/5952-93-2.gif)
5952-93-2
65 suppliers
$60.00/100mg
![Methyl 5-aMino-1-Methyl-1H-pyrazole-4-carboxylate](/CAS/20150408/GIF/110860-60-1.gif)
110860-60-1
34 suppliers
$44.00/250mg
![5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid](/CAS/GIF/88398-85-0.gif)
88398-85-0
22 suppliers
inquiry
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/5952-93-2.gif)
5952-93-2
65 suppliers
$60.00/100mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$9.00/25ml
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/5952-92-1.gif)
5952-92-1
232 suppliers
$5.00/250mg
![1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/5952-93-2.gif)
5952-93-2
65 suppliers
$60.00/100mg