6-chloro-N4-ethylpyrimidine-4,5-diamine synthesis

4synthesis methods

Product Name:6-chloro-N4-ethylpyrimidine-4,5-diamine
CAS Number:98140-03-5
Molecular formula:C6H9ClN4
Molecular Weight:172.62

5413-85-4 Synthesis

5413-85-4
341 suppliers
$15.00/5G

75-04-7
381 suppliers
$10.00/20mg

98140-03-5
27 suppliers
inquiry

Yield:98140-03-5 93%

Reaction Conditions:

with triethylamine in ethanol at 150; for 27 h;

Steps:

3 4.1.1. General procedure for the synthesis of N⁴-alkyl-4,5-diamino-6-chloropyrimidine 6-8

General procedure: A solution of 5-amino-4,6-dichloropyrimidine (5, 1.0 mmol),triethylamine (1.0 mmol), ethanol (4.3 mL), and the appropriateamine (2.5 mmol) was heated in a steel vial for the time specifiedfor each compound. After the removal of volatiles in vacuo, thecrude was purified as described for each compound.

References:

Lambertucci, Catia;Marucci, Gabriella;Dal Ben, Diego;Buccioni, Michela;Spinaci, Andrea;Kachler, Sonja;Klotz, Karl-Norbert;Volpini, Rosaria [European Journal of Medicinal Chemistry,2018,vol. 151,p. 199 - 213]

5413-85-4 Synthesis

5413-85-4
341 suppliers
$15.00/5G

557-66-4 Synthesis