![](/CAS/GIF/75680-92-1.gif)
6-Chloro-pyridazine-3-carboxylic acid ethyl ester synthesis
- Product Name:6-Chloro-pyridazine-3-carboxylic acid ethyl ester
- CAS Number:75680-92-1
- Molecular formula:C7H7ClN2O2
- Molecular Weight:186.6
![5-Chloropyridazine-3-carboxylic acid](/CAS/20150408/GIF/1211587-01-7.gif)
1211587-01-7
36 suppliers
$122.00/25mg
![6-Chloro-pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/75680-92-1.gif)
75680-92-1
133 suppliers
$55.00/250mg
Yield: 150 mg (52%)
Reaction Conditions:
with 2-(Dimethylamino)pyridine in ethanol
Steps:
170.C Ethyl 3-chloropyridazine-6-carboxylate
The carboxylic acid (243 mg, 1.53 mmol) was dissolved in ~15 mL of ethanol and treated with 24 mg (0.2 mmol) of dimethylaminopyridine (DMAP) followed by 324 mg (1.69 mmol) 1-(3-dimethylaminopropyl-3-ethylcarbodiimide hydrochloride (EDCl). The reaction was stirred at ambient temperature for 4 hours and then worked up by the procedure described in Example 166A. The crude product was purified by flash chromatography on silica gel to give 150 mg (52%) of the title compound as a white crystalline solid. 1 H NMR (CDCl3, 300 MHz) δ 1.45 (t, 3H), 4.55 (q, 2H), 7.65 (d, 1H), 8.15 (d, 1H). MS (DCl/NH3) m/e 187/189 (M+H)+, 204/206 (M+H+NH3)+.
References:
Abbott Laboratories US5250548, 1993, A
![1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER](/CAS/GIF/63001-31-0.gif)
63001-31-0
87 suppliers
$65.00/100mg
![6-Chloro-pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/75680-92-1.gif)
75680-92-1
133 suppliers
$55.00/250mg
![1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER](/CAS/GIF/63001-31-0.gif)
63001-31-0
87 suppliers
$65.00/100mg
![6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid](/CAS/GIF/37972-69-3.gif)
37972-69-3
158 suppliers
$10.00/1g
![6-Chloro-pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/75680-92-1.gif)
75680-92-1
133 suppliers
$55.00/250mg
![1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER](/CAS/GIF/63001-31-0.gif)
63001-31-0
87 suppliers
$65.00/100mg
![6-Chloro-pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/75680-92-1.gif)
75680-92-1
133 suppliers
$55.00/250mg
![2-Ketoglutaric acid](/CAS/GIF/328-50-7.gif)
328-50-7
550 suppliers
$6.00/25g
![6-Chloro-pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/75680-92-1.gif)
75680-92-1
133 suppliers
$55.00/250mg