![](/CAS/GIF/65202-50-8.gif)
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE synthesis
- Product Name:METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
- CAS Number:65202-50-8
- Molecular formula:C6H5ClN2O2
- Molecular Weight:172.57
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![6-Chloropyridazine-3-carboxylic acid](/CAS/GIF/5096-73-1.gif)
5096-73-1
184 suppliers
$15.00/1g
![METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/65202-50-8.gif)
65202-50-8
177 suppliers
$21.21/1gm:
Yield:65202-50-8 88.2%
Reaction Conditions:
Stage #1:6-chloro-pyridazine-3-carboxylic acid with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 0 - 20; for 1 h;
Stage #2:methanol in dichloromethane at 20; for 1 h;
Steps:
1.11; 1.13
Oxalyl chloride (1 equiv.) was added dropwise to a solution of 6-chloro-3- pyridazinecarboxylic acid (1.000 g, 6.308 mmol) in dry DCM (30 mL) and dry DMF (1 drop) at 0 °C and the mixture stirred at this temperature for 1 h. The solvent was removed in vacuo and the residue redissolved in dry DCM. MeOH (1 equiv.) were added and the mixture stirred at rt for a further 1 h. The mixture was quenched with H2O (20 mL) and extracted with DCM (2 x 20 mL). The combined organic layers were then dried over MgSO4and concentrated to give methyl 6-chloropyridazine-3-carboxylate as a white solid. (0.960 g, 88.2% yield). NMR (400 MHz, CDCl3) d 8.17 (d, J = 8.8 Hz, 1H), 7.68 (d, J = 8.8 Hz, 1H), 4.09 (s, 3H).
References:
CINCERA THERAPEUTICS PTY LTD WO2021/12018, 2021, A1 Location in patent:Page/Page column 63; 85; 90-91
![METHYL 6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/63001-30-9.gif)
63001-30-9
109 suppliers
$9.00/250mg
![METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/65202-50-8.gif)
65202-50-8
177 suppliers
$21.21/1gm:
![METHYL 6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/63001-30-9.gif)
63001-30-9
109 suppliers
$9.00/250mg
![METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/65202-50-8.gif)
65202-50-8
177 suppliers
$21.21/1gm:
![6-chloropyridazine-3-carbonyl chloride](/CAS/GIF/6531-04-0.gif)
6531-04-0
17 suppliers
$279.23/1gm:
![METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/65202-50-8.gif)
65202-50-8
177 suppliers
$21.21/1gm:
![6-Chloropyridazine-3-carboxylic acid](/CAS/GIF/5096-73-1.gif)
5096-73-1
184 suppliers
$15.00/1g
![Sodium Methoxide](/CAS/GIF/124-41-4.gif)
124-41-4
682 suppliers
$12.00/25g
![METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE](/CAS/GIF/65202-50-8.gif)
65202-50-8
177 suppliers
$21.21/1gm: