6-Methoxy-2-(p-tolyl)quinoline-4-carboxylic acid synthesis
- Product Name:6-Methoxy-2-(p-tolyl)quinoline-4-carboxylic acid
- CAS Number:18193-09-4
- Molecular formula:C18H15NO3
- Molecular Weight:293.32
Yield:18193-09-4 65%
Reaction Conditions:
with potassium hydroxide in ethanol;water;Reflux;Pfitzinger Quinoline Synthesis;
Steps:
3 General method for the synthesis of compounds (1a-d)
General procedure: A mixture of 5-methoxyisatin, (10mmol), 33% potassium hydroxide (10ml) in ethanol (20ml), and 4-substituted acetophenone (10mmol) was heated under reflux for 9-18h. The reaction mixture was concentrated under reduced pressure and the residue was diluted with water (50ml) and extracted with ether (3×50ml). The aqueous layer was neutralized with 1M hydrochloric acid. The precipitated solid was filtered, washed with water, dried and crystallized from ethanol.
References:
El-Feky, Said A. H.;Abd El-Samii, Zakaria K.;Osman, Nermine A.;Lashine, Jasmine;Kamel, Mohamed A.;Thabet, Hamdy Kh. [Bioorganic Chemistry,2015,vol. 58,p. 104 - 116]
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519 suppliers
$5.00/10g
18193-09-4
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