ChemicalBook CAS DataBase List 6-Methyl-2-(methylthio)pyrimidin-4-ol

6-Methyl-2-(methylthio)pyrimidin-4-ol synthesis

6synthesis methods

Product Name:6-Methyl-2-(methylthio)pyrimidin-4-ol
CAS Number:6328-58-1
Molecular formula:C6H8N2OS
Molecular Weight:156.21

56-04-2 Synthesis

56-04-2
356 suppliers
$5.00/100mg

74-88-4
341 suppliers
$15.00/10g

6328-58-1
92 suppliers
$10.60/1gm:

Yield: 98%

Reaction Conditions:

with sodium hydroxide in water at 20; for 4 h;

Steps:

1.1.1 Step 1: Synthesis of 6-methyl-2-(methylsulfanyl)-3,4-dihydropyrimidin-4-one
(EV-AO5743-001) [00128] To water (500 mL) was added NaOH (97%, 15.7 g, 381 mmol) and the suspension stirred at r.t. for 10 mins. 6-methyl-2-sulfanylidene-l,2,3,4-tetrahydropyrimidin-4-one (98%, 53.5 g, 369mmol) was added and the mixture stirred until fully dissolved for 10 mins. lodomethane (28.99 mL, 461 mmol) was added dropwise and the mixture stirred at r.t. for 4 h. The colorless solid was filtered, washed with ice cold water (2 x 100 mL) and dried under vacuum at 60 °C to afford the title compound (57 g, 98%) as a colorless solid. [00129] Method A: LC-MS m/z = 156.9 [M + H]⁺; RT = 0.61 min.

References:

QUARTET MEDICINE, INC.;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL);TEBBE, Mark, Joseph;ATTON, Holly, Victoria;AVERY, Craig;BROMIDGE, Steven, Mark;KERRY, Mark;KOTEY, Adrian, Kotei;MONCK, Nathaniel, J.;MENICONI, Mirco;RIDGILL, Mark, Peter;TYE, Heather;SAIAH, Eddine;JOHNSSON, Kai, Peter;GORSKA, Katarzyna, Irena;PENG, Hairuo;MCCALL, John, Michael WO2017/59191, 2017, A1 Location in patent:Paragraph 00126-00129

56-04-2 Synthesis

56-04-2
356 suppliers
$5.00/100mg

74-88-4
341 suppliers
$15.00/10g

6328-58-1
92 suppliers
$10.60/1gm:

References

141-97-9 Synthesis