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Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate synthesis

1synthesis methods
1126-09-6 Synthesis
Ethyl 4-piperidinecarboxylate

1126-09-6
489 suppliers
$15.40/25g

65753-47-1 Synthesis
2-Chloro-3-(trifluoromethyl)pyridine

65753-47-1
366 suppliers
$8.00/5g

Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate

801306-50-3
12 suppliers
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Yield:801306-50-3 75%

Reaction Conditions:

with potassium carbonate in acetonitrile at 100; for 22.5 h;

References:

Schwarz, Maria C.;Dastbaravardeh, Navid;Kirchner, Karl;Schnuerch, Michael;Mihovilovic, Marko D. [Monatshefte fur Chemie,2013,vol. 144,# 4,p. 539 - 552]