3H-IMidazo[4,5-c]pyridine-6-carboxylic acid, Methyl ester synthesis

9synthesis methods

Product Name:3H-IMidazo[4,5-c]pyridine-6-carboxylic acid, Methyl ester
CAS Number:82523-07-7
Molecular formula:C8H7N3O2
Molecular Weight:177.16

1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 4,5,6,7-tetrahydro-, methyl ester, (6S)-

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3H-IMidazo[4,5-c]pyridine-6-carboxylic acid, Methyl ester

82523-07-7
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$71.00/100mg

Yield:82523-07-7 82%

Reaction Conditions:

with potassium permanganate;triethylamine in N,N-dimethyl-formamide; pH=8; for 12 h;

Steps:

3 Example 3 Preparation of 3H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester

4 g (22.1 mmol) of (6S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester200 mL of dimethylformamide was dissolved, and the pH was adjusted to 8 with triethylamine.500mg KMnO4 was added in 3 times in an ice bath.Stir for 12 h.The reaction mixture was concentrated under reduced vacuo.The insoluble matter was removed by filtration. The filtrate was adjusted to pH 7 with an aqueous NaOH solution in an ice bath.The colorless solid was filtered after analysis. The filter cake was washed with distilled water and allowed to dry at room temperature.Having 3.715 g (82%) of the title compound,It is a colorless solid.

References:

CN108976225,2018,A Location in patent:Paragraph 0025; 0026