4-[(ETHYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 98%4-(3-ETHYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER synthesis
- Product Name:4-[(ETHYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 98%4-(3-ETHYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER
- CAS Number:874291-00-6
- Molecular formula:C15H23BN2O3
- Molecular Weight:290.17
82745-18-4
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$503.56/5MG
25015-63-8
223 suppliers
$22.39/5G
874291-00-6
50 suppliers
$50.00/250mg
Yield:874291-00-6 84%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium carbonate in 1,4-dioxane at 100; for 2 h;
Steps:
4.2 Step 2
under the protection of nitrogen, 1 - (4 - bromophenyl) -3 - ethyl urea (2.0g, 8 . 22mmol), joint boric acidfrequency that alcohol ester (4.18g, 16 . 5mmol), Pd (dppf) Cl2(600 mg, 0 . 82mmol), potassium acetate (1.21g, 12 . 3mmol) with 1, 4 - dioxane (50 ml) mixed, heated to 100 °C stirring 2 hours. Cooling to room temperature, concentrated under reduced pressure. Residue in water, extracted with ethyl acetate, dried, concentrated, silica gel column chromatography 1 - ethyl -3 - (4 - boronic acid pinacone ester -2 - yl) phenyl) urea (2.0g, 84%).
References:
CN104557955,2017,B Location in patent:Paragraph 0168; 0170
82745-18-4
17 suppliers
$503.56/5MG
73183-34-3
573 suppliers
$6.00/5g
874291-00-6
50 suppliers
$50.00/250mg
106-40-1
464 suppliers
$12.00/5g
874291-00-6
50 suppliers
$50.00/250mg