3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER synthesis
- Product Name:3-IODO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLICACIDMETHYLESTER
- CAS Number:944937-30-8
- Molecular formula:C9H7IN2O2
- Molecular Weight:302.07
![1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/849067-96-5.gif)
849067-96-5
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944937-30-8
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Yield:944937-30-8 80.19%
Reaction Conditions:
with N-iodo-succinimide in propan-2-one at 20; for 1 h;Inert atmosphere;
Steps:
11.II Part II - Synthesis of methyl 3-iodo-1H -pyrrolo[2,3-b]pyridine-5-carboxylate
A solution/mixture of methyl lH-pyrrolo[2,3-b]pyridine-5-carboxylate (8 g, 45.409 mmol, 1.00 equiv) and NIS (12.26 g, 54.491 mmol, 1.2 equiv) in acetone (240 mL) was stirred for 1 h at room temperatureunder nitrogenatmosphere. The resulting mixture was concentrated under vacuum. The resulting mixture was diluted with 1 M sodium thiosulfate pentahydrate (100 mL). The resulting mixture was washed with 3 x 50 mL of water. The resulting solid was dried in an oven under reduced pressure. This resulted in methyl 3-iodo-lH-pyrrolo[2,3-b]pyridine-5- carboxylate (11 g, 80.19%) as a brown yellow solid.
References:
WO2022/51569,2022,A1 Location in patent:Paragraph 0801-0802
183208-35-7
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$5.00/1g
944937-30-8
50 suppliers
$60.00/100mg