(3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(2-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)ethyl)azetidin-2-one synthesis

10synthesis methods

Product Name:(3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(2-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)ethyl)azetidin-2-one
CAS Number:953805-24-8
Molecular formula:C36H35F2NO4
Molecular Weight:583.66

(3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(2-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)ethyl)azetidin-2-one

953805-22-6
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953805-24-8
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Yield:953805-24-8 79%

Reaction Conditions:

with N,O-Bis(trimethylsilyl)acetamide;tetrabutyl ammonium fluoride in toluene; for 48 h;Reflux;

Steps:

6 Synthesis of Compound VI

Take a 250ml single neck bottle, Were sequentially added dry toluene 150ml, compound V (74.6g, 0.1mol), Bis (trimethylsilyl) acetamide (BSA) (40.6g, 0.2mol), After refluxing, the reaction was refluxed for 24 hours, Then tetrabutylammonium fluoride (TBAF) (13.1 g, 0.05 mol) was added, The reaction was continued for 24 hours, Cooled to precipitate a solid, Filter, The filter cake was recrystallized from petroleum ether to give 46.1 g of a white solid VI, Yield 79%.

References:

CN106397292,2017,A Location in patent:Paragraph 0053; 0054; 0098; 0099

126-30-7 Synthesis