ChemicalBook CAS DataBase List Apixaban Impurity 22

Apixaban Impurity 22 synthesis

2synthesis methods

Product Name:Apixaban Impurity 22
CAS Number:405872-78-8
Molecular formula:C11H13ClN2O3
Molecular Weight:256.69

536-90-3 Synthesis

536-90-3
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$10.00/5g

609-15-4 Synthesis

609-15-4
445 suppliers
$6.00/25g

405872-78-8
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Yield:405872-78-8 69%

Reaction Conditions:

Stage #1: m-Anisidinewith hydrogenchloride;sodium nitrite in water at 5;
Stage #2: ethyl 2-chloro-3-oxo-butyrate in water at 1 - 20;

References:

Peng, Youyi;Zhang, Qiang;Arora, Sonia;Keenan, Susan M.;Kortagere, Sandhya;Wannemacher, Kenneth M.;Howells, Richard D.;Welsh, William J. [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 17,p. 6442 - 6450] Location in patent:experimental part

609-15-4 Synthesis

609-15-4
445 suppliers
$6.00/25g

405872-78-8
31 suppliers
inquiry

References

Apixaban Impurity 22 Related Search:

Apixaban Impurity 42 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban-d3 Apixaban Impurity 51 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester Apixaban Impurity 22 ethyl (E)-2-(2-(4-methoxyphenyl)hydrazono)propanoate