![](/CAS/GIF/21725-69-9.gif)
BENZO[D]ISOXAZOL-3-OL synthesis
- Product Name:BENZO[D]ISOXAZOL-3-OL
- CAS Number:21725-69-9
- Molecular formula:C7H5NO2
- Molecular Weight:135.12
![Salicylhydroxamic acid](/CAS/GIF/89-73-6.gif)
89-73-6
240 suppliers
$14.00/5g
![BENZO[D]ISOXAZOL-3-OL](/CAS/GIF/21725-69-9.gif)
21725-69-9
116 suppliers
$16.96/250mgs:
Yield: 100%
Reaction Conditions:
Stage #1:salicylhydroxamic acid with 1,1'-carbonyldiimidazole in tetrahydrofuran at 60; for 2.5 h;Heating / reflux;
Stage #2: with hydrogenchloride in water; pH=2 at 10 - 15; for 0.5 h;
Steps:
A1.b
A solution of intermediate 1 (1,92 M in THF) was stirred at 60°C. A solution of CDI (3,84 M in THF) was added over 30 min. under reflux to the aforementioned solution and refluxed for another 2 hours at 60°C. The reaction mixture was cooled to 40°C and the solvent evaporated. After completion, the remaining residue was quenched with water and acidified with 12N HCI to pH 2. The mixture was stirred for 30 min. at 10- 15°C and the resulting precipitate filtrated, washed with ice-water and dried under reduced pressure at 90 °C. Quantitative Yielding 3-Hydroxybenzisoxazole (intermediate 2).
References:
JANSSEN PHARMACEUTICA N.V. WO2005/89753, 2005, A2 Location in patent:Page/Page column 27
![Methyl salicylate](/CAS/GIF/119-36-8.gif)
119-36-8
990 suppliers
$5.00/10g
![BENZO[D]ISOXAZOL-3-OL](/CAS/GIF/21725-69-9.gif)
21725-69-9
116 suppliers
$16.96/250mgs:
![Salicylhydroxamic acid](/CAS/GIF/89-73-6.gif)
89-73-6
240 suppliers
$14.00/5g
![BENZO[D]ISOXAZOL-3-OL](/CAS/GIF/21725-69-9.gif)
21725-69-9
116 suppliers
$16.96/250mgs:
![Salicylic acid](/CAS/GIF/69-72-7.gif)
69-72-7
1226 suppliers
$5.00/10g
![BENZO[D]ISOXAZOL-3-OL](/CAS/GIF/21725-69-9.gif)
21725-69-9
116 suppliers
$16.96/250mgs: