ChemicalBook CAS DataBase List BIS(2-METHOXYETHOXY)METHANE

BIS(2-METHOXYETHOXY)METHANE synthesis

4synthesis methods

Product Name:BIS(2-METHOXYETHOXY)METHANE
CAS Number:4431-83-8
Molecular formula:C7H16O4
Molecular Weight:164.2

50-00-0 Synthesis

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4431-83-8
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Yield: 94.4%

Reaction Conditions:

with Amberlyst₁₅ catalyst in water;tolueneReflux;Reagent/catalyst;Solvent;

Steps:

1-8 Example Two
In a 1000 mL three-neck reaction flask, 30 g of paraformaldehyde, 193.2 g of 2-methoxyethanol, and 25 g of Amberlyst15 catalyst were added. 500 mL of toluene with water was added, and a water separator was added. The temperature was raised until toluene refluxed with water until no more water was formed. Reduce the temperature to room temperature, filter off the catalyst, evaporate toluene, and add 5 g of potassium carbonate to neutralize the catalyst, filter off potassium carbonate and otherSalt, add 75 mL × 2 double distilled water, and collect the oil phase after layering. The oil phase was dried with anhydrous magnesium sulfate, and then distilled under reduced pressure. A 100-101C fraction at a pressure of 24 mm Hg was collected to obtain 155 g of a product with a yield of 94.4%.

References:

Shenzhen Qian Haiboyang Institute Co., Ltd.;Xiong Donglu;Mo Zhiwen;Yang Xuan;Xu Tao;Xiao Zengjun CN110511124, 2019, A Location in patent:Paragraph 0041-0056