BOC-L-4-Nitrophe synthesis

Yield:33305-77-0 88%

Reaction Conditions:

in tetrahydrofuran;sodium hydroxide

Steps:

48.A (S)-N-boc-4-nitrophenylalanine
Example 48A (S)-N-boc-4-nitrophenylalanine To a solution of (S)-4-nitrophenylalanine (2.00 g, 9.51 mmol) in aqueous 2M NaOH (10 mL) and THF (5 mL), was added di-tertbutyldicarbonate (2.00 g, 9.17 mmol) in THF (5 mL). The reaction was stirred at ambient temperature for 1 hour, diluted with H₂O (25 mL) and 1M HCl (25 mL), extracted with ether (3*25 mL). The combined ether layers were extracted with brine (1*25 mL), dried (MgSO₄), filtered, and concentrated under reduced pressure to provide the titled compound (2.51 g, 88%).

References:

Liu, Gang;Szczepankiewicz, Bruce G.;Pei, Zhonghua;Xin, Zhili;Oost, Thorsten K.;Janowick, David A. US2002/35137, 2002, A1

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