CHEMBRDG-BB 6382736 synthesis

11synthesis methods

Product Name:CHEMBRDG-BB 6382736
CAS Number:27906-91-8
Molecular formula:C11H17N
Molecular Weight:163.26

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27906-91-8
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Yield:27906-91-8 91%

Reaction Conditions:

with C₂₀H₂₅Cl₂CoN₃;sodium triethylborohydride in 1,2-dimethoxyethane at 100; for 6 h;Inert atmosphere;

Steps:

19 Example 19: Reduction of N-(2-phenylethyl)propionamide to N-propylphenethylamine:

Under an inert atmosphere, the substrate N-(2-phenylethyl)propionamide (177 mg, 1 mmol), polymethylhydrosiloxane (668 μL, 3 mmol), and Co-2 catalyst (9.0 mg, 0.02 mmol), sodium triethylborohydride (40 μL, 0.04 mmol), and ethylene glycol dimethyl ether (2 mL), and the resulting mixture was stirred well.The reaction was carried out in an oil bath at 100°C for 6 h, the reaction system was cooled to room temperature, ethyl acetate was added to dilute and quench, and concentrated, and the crude product was obtained by flash silica gel column chromatography to obtain 148 mg of light yellow oily liquid, yield: 91%.

References:

CN114031477,2022,A Location in patent:Paragraph 0087-0089