ChemicalBook CAS DataBase List Dabigatran iMpurity L

Dabigatran iMpurity L synthesis

1synthesis methods

Product Name:Dabigatran iMpurity L
CAS Number:1422435-41-3
Molecular formula:C27H28N6O4
Molecular Weight:500.55

3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester

211915-84-3
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1422435-41-3
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Yield:-

Reaction Conditions:

Stage #1:3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester with hydrogenchloride in ethanol;dichloromethane at 15 - 30; for 6 h;
Stage #2: with ammonia in ethanol

References:

ALEMBIC PHARMACEUTICALS LIMITED;JAYARAMAN, Venkatraman;PATEL, Samir;MISTRY, Samir;TIMBADIYA, Mukesh;PARMAR, Bhupendra;TAMBOLI, Parimal WO2013/24394, 2013, A1 Location in patent:Page/Page column 20; 2

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