Dapsone-D8 (major) synthesis
- Product Name:Dapsone-D8 (major)
- CAS Number:557794-38-4
- Molecular formula:C12H4D8N2O2S
- Molecular Weight:256.35
80-08-0
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557794-38-4
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$153.00/500μg
Yield:557794-38-4 96%
Reaction Conditions:
with water-d2;platinum on carbon;palladium 10% on activated carbon at 180; for 24 h;Product distribution / selectivity;
Steps:
8
Reference Example 8 Synthesis of Deuterated 4,4'-diaminodiphenylsulfone 4,4'-diaminodiphenylsulfone of 10 g and a mixed catalyst of 3 g composed of 10% Pd/C of 1 g and 5% Pt/C of 2 g were added to deuterated water (D2O) of 340 mL and subjected to reaction at about 180° C. for 24 hours. After termination of the reaction, the reaction product was purified similarly as in Reference Example 1 to obtain deuterated 4,4'-diaminodiphenylsulfone of 9-6 g (yield: 96%). The obtained deuterated 4,4'-diaminodiphenylsulfone was subjected to structural analysis by measuring its 1H-NMR and 2H-NMR spectra to show an average deuteration ratio of 47%
References:
US2008/45724,2008,A1 Location in patent:Page/Page column 18
557794-37-3
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557794-38-4
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4165-61-1
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$56.00/1ml
557794-38-4
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15826-91-2
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$425.00/10mg
557794-38-4
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$153.00/500μg
557794-36-2
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557794-38-4
32 suppliers
$153.00/500μg