![](/CAS/GIF/15307-78-5.gif)
DICLOFENAC METHYL ESTER synthesis
- Product Name:DICLOFENAC METHYL ESTER
- CAS Number:15307-78-5
- Molecular formula:C15H13Cl2NO2
- Molecular Weight:310.18
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$7.29/5ml-f
![1-(2,6-Dichlorophenyl)-2-indolinone](/CAS/GIF/15307-86-5.gif)
15307-86-5
363 suppliers
$48.00/25g
![DICLOFENAC METHYL ESTER](/CAS/GIF/15307-78-5.gif)
15307-78-5
83 suppliers
$35.00/10mg
Yield: 96%
Reaction Conditions:
with sulfuric acid for 0.25 h;Reflux;
Steps:
3.1.4.2. Diclofenac Methyl Ester (2)
Diclofenac acid (5 g) was dissolved in methanol (80 mL)with stirring and sulfuric acid (3 mL) was added drop wisewith continuous stirring and the mixture was heated underreflux for 15 min. After completion of the reaction (TLCanalysis), it was cooled to room temperature and poured ontocrushed ice (250 g) to obtain crystalline solid (2) which wasfiltered, washed with water followed by 5% sodium hydrogencarbonate solution, finally with water and dried in air.
References:
Shah, Shazia;Arshia;Kazmi, Nida Siraj;Jabeen, Almas;Khan, Khalid Mohammed;Raza, Abeer;Faheem, Aisha;Dastagir, Nida;Ahmed, Tariq;Ahmed, Shakil;Perveen, Shahnaz [Medicinal Chemistry,2018,vol. 14,# 7,p. 674 - 687]
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
129 suppliers
$6.00/1g
![2,6-Dichloroaniline](/CAS/GIF/608-31-1.gif)
608-31-1
301 suppliers
$12.00/25g
![DICLOFENAC METHYL ESTER](/CAS/GIF/15307-78-5.gif)
15307-78-5
83 suppliers
$35.00/10mg
![Methyl 2-(2-iodophenyl)acetate](/CAS/20180703/GIF/66370-75-0.gif)
66370-75-0
24 suppliers
inquiry
![2,6-Dichloroaniline](/CAS/GIF/608-31-1.gif)
608-31-1
301 suppliers
$12.00/25g
![DICLOFENAC METHYL ESTER](/CAS/GIF/15307-78-5.gif)
15307-78-5
83 suppliers
$35.00/10mg
![Diclofenac sodium](/CAS/GIF/15307-79-6.gif)
15307-79-6
856 suppliers
$14.00/5g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![DICLOFENAC METHYL ESTER](/CAS/GIF/15307-78-5.gif)
15307-78-5
83 suppliers
$35.00/10mg
![1-(2,6-Dichlorophenyl)-2-indolinone](/CAS/GIF/15307-86-5.gif)
15307-86-5
363 suppliers
$48.00/25g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
207 suppliers
$33.00/5g
![DICLOFENAC METHYL ESTER](/CAS/GIF/15307-78-5.gif)
15307-78-5
83 suppliers
$35.00/10mg