![](/CAS/GIF/57486-69-8.gif)
METHYL 2-(2-BROMOPHENYL)ACETATE synthesis
- Product Name:METHYL 2-(2-BROMOPHENYL)ACETATE
- CAS Number:57486-69-8
- Molecular formula:C9H9BrO2
- Molecular Weight:229.07
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-Bromophenylacetic acid](/CAS/GIF/18698-97-0.gif)
18698-97-0
333 suppliers
$10.00/1g
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
130 suppliers
$6.00/1g
Yield:57486-69-8 99%
Reaction Conditions:
with sulfuric acid for 0.5 h;Reflux;
Steps:
General procedure for the synthesis of compounds S5a-S5d (UsingS5a as a representative)
General procedure: A solution of S4a (5.0 g, 18.18 mmol) and conc. H2SO4 (catalytic) in methanol (50 mL) was refluxed for 30 min. After 30 min, the reaction mixture was cooled to rt and was evaporated under reduced pressure. To the resulting crude water (30 mL) was added, followed by extraction with three portions of 20 mL of dichloromethane. The combined organic layer was dried over Na2SO4, and evaporated under reduced pressure to afford S5a. methyl 2-(2-bromo-4,5-dimethoxyphenyl)acetate (S5a): Brown Oil; (5.19 g, 99 %). methyl 2-(2-bromo-5-methoxyphenyl)acetate (S5b): Brown Oil; (2.09 g,99 %). methyl 2-(2-bromo-4-methoxyphenyl)acetate (S5c): Brown Oil; (2.09 g, 99 %). methyl 2-(2-bromophenyl)acetate (S5d): Clear Oil; (5.27 g, 99 %).
References:
Kapadia, Nirav;Harding, Wayne [Tetrahedron,2013,vol. 69,# 42,p. 8914 - 8920] Location in patent:supporting information
![2-Bromophenylacetic acid](/CAS/GIF/18698-97-0.gif)
18698-97-0
333 suppliers
$10.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
208 suppliers
$33.00/5g
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
130 suppliers
$6.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![1-ACETOXY-2-BROMOBENZENE](/CAS/GIF/1829-37-4.gif)
1829-37-4
45 suppliers
$73.32/0.5g
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
130 suppliers
$6.00/1g
![2-Bromophenylacetic acid](/CAS/GIF/18698-97-0.gif)
18698-97-0
333 suppliers
$10.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
342 suppliers
$15.00/10g
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
130 suppliers
$6.00/1g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-BROMOPHENYLACETYL CHLORIDE](/CAS/GIF/55116-09-1.gif)
55116-09-1
27 suppliers
$405.00/25ml
![METHYL 2-(2-BROMOPHENYL)ACETATE](/CAS/GIF/57486-69-8.gif)
57486-69-8
130 suppliers
$6.00/1g