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ChemicalBook CAS DataBase List DIETHYL 4-METHOXYPHENYL MALONATE
23197-67-3

DIETHYL 4-METHOXYPHENYL MALONATE synthesis

12synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 96 percent / conc. HCl / Heating
2: 75 percent / NaH / hexane; tetrahydrofuran / 60 °C

References:

Matulenko, Mark A.;Paight, Ernest S.;Frey, Robin R.;Gomtsyan, Arthur;DiDomenico Jr., Stanley;Jiang, Meiqun;Lee, Chih-Hung;Stewart, Andrew O.;Yu, Haixia;Kohlhaas, Kathy L.;Alexander, Karen M.;McGaraughty, Steve;Mikusa, Joseph;Marsh, Kennan C.;Muchmore, Steven W.;Jakob, Clarissa L.;Kowaluk, Elizabeth A.;Jarvis, Michael F.;Bhagwat, Shripad S. [Bioorganic and Medicinal Chemistry,2007,vol. 15,# 4,p. 1586 - 1605]