ChemicalBook CAS DataBase List DIMETHYL 5-BROMOISOPHTHALATE

DIMETHYL 5-BROMOISOPHTHALATE synthesis

9synthesis methods

Product Name:DIMETHYL 5-BROMOISOPHTHALATE
CAS Number:51760-21-5
Molecular formula:C10H9BrO4
Molecular Weight:273.08

23351-91-9 Synthesis

23351-91-9
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51760-21-5
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$6.00/1g

Yield:51760-21-5 89%

Reaction Conditions:

with sulfuric acid;sodium hydrogencarbonate in methanol

Steps:

3 [Preparation of dimethyl 5-bromoisophthalate from 5-bromoisophthalic acid]
[Preparation of dimethyl 5-bromoisophthalate from 5-bromoisophthalic acid] Into a 500 ml flask equipped with a stirrer and a Dimroth condenser, 110 g of 5-bromoisophthalic acid obtained above, 500 ml of methanol and 10 g of a concentrated sulfuric acid were placed and the resultant mixture was heated under the refluxing condition for 6 hours. After the reaction mixture was cooled by being left standing, the cooled mixture was added dropwise to 1 liter of distilled water and the obtained mixture was neutralized with a 5% by weight aqueous solution of sodium hydrogencarbonate. The formed precipitates were separated by filtration and washed twice with 2 liters of distilled water. The obtained white solid substance was dried at 50ØC under a reduced pressure for 2 days and 109 g (0.4 moles) of dimethyl 5-bromoisophthalate was obtained (the yield: 89%).

References:

SUMITOMO BAKELITE CO., LTD. EP1346975, 2003, A1

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99-27-4 Synthesis