![](/CAS/GIF/14527-42-5.gif)
Ethyl thiazole-2-carboxylate synthesis
- Product Name:Ethyl thiazole-2-carboxylate
- CAS Number:14527-42-5
- Molecular formula:C6H7NO2S
- Molecular Weight:157.19
![2-(Trimethylsilyl)thiazole](/CAS/GIF/79265-30-8.gif)
79265-30-8
183 suppliers
$22.00/1g
![Ethyl chloroformate](/CAS/GIF/541-41-3.gif)
541-41-3
6 suppliers
$19.39/5g
![Ethyl thiazole-2-carboxylate](/CAS/GIF/14527-42-5.gif)
14527-42-5
85 suppliers
$9.00/100mg
Yield: 99%
Reaction Conditions:
Stage #1:2-(trimethylsilyl)thiazole;chloroformic acid ethyl ester in toluene at 22; for 2.25 h;
Stage #2: with water;sodium carbonate in toluene for 0.5 h;
Steps:
9
Preparation 9Thiazole-2-carboxylic acid ethyl esterTo a mixture of 2-trimethylsilylthiazole (135 g, 858.1 mmol) in toluene (1350 mL) add a solution of ethyl chloroformate (98.4 mL, 1.03 mol) in toluene (1350 mL) over 15 min. Stir the reaction at 22 0C for 2 h. Add the solution over aqueous sodium carbonate 25% (wt/wt) (5 L) and stir for 30 min. Separate the organic layer and re-extract the aqueous layer with methylene chloride (2 x 1 L). Combine the organic layers and evaporate the solvent to provide the title compound (134 g, 99%). ES/MS m/z 158 (M+l)+.
References:
ELI LILLY AND COMPANY WO2008/36579, 2008, A1 Location in patent:Page/Page column 26
![2-(Trimethylsilyl)thiazole](/CAS/GIF/79265-30-8.gif)
79265-30-8
183 suppliers
$22.00/1g
![Ethyl chloroformate](/CAS/GIF/541-41-3.gif)
541-41-3
6 suppliers
$19.39/5g
![Ethyl thiazole-2-carboxylate](/CAS/GIF/14527-42-5.gif)
14527-42-5
85 suppliers
$9.00/100mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
![Chloroacetaldehyde](/CAS/GIF/107-20-0.gif)
107-20-0
4 suppliers
$18.10/5ml
![Ethyl thiooxamate](/CAS/GIF/16982-21-1.gif)
16982-21-1
230 suppliers
$6.00/1g
![Acetic anhydride](/CAS/20180808/GIF/108-24-7.gif)
108-24-7
5 suppliers
$14.00/250ML
![Ethyl thiazole-2-carboxylate](/CAS/GIF/14527-42-5.gif)
14527-42-5
85 suppliers
$9.00/100mg