Imidazo[1,2-a]pyridine, 7-methoxy- (9CI) synthesis
- Product Name:Imidazo[1,2-a]pyridine, 7-methoxy- (9CI)
- CAS Number:342613-71-2
- Molecular formula:C8H8N2O
- Molecular Weight:148.16
107-20-0
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10201-73-7
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342613-71-2
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$139.00/250mg
Yield:342613-71-2 87%
Reaction Conditions:
with sodium hydrogencarbonate in ethanol at 78; for 4 h;
Steps:
1.1 Step 1: Preparation of 7-methoxyimidazo[1,2-a]pyridine (1a)
Add 4-methoxypyridin-2-amine (7.37g, 59.4mol) and 2-chloroacetaldehyde (11.64g, 148.6mol) into a clean flask and dissolve it with 25mL of ethanol.Add sodium bicarbonate (9.98 g, 118.9 mol). After stirring for 4 hours at room temperature of 78°C,Extract and separate with ethyl acetate and water, combine the organic phases, and dry with anhydrous sodium sulfate,After spin-drying the solvent and column chromatography (dichloromethane/methanol=30:1, V/V), a brown oily pure product was obtained, and the desired product (9.95 g, 87.0%) was obtained.
References:
CN113620943,2021,A Location in patent:Paragraph 0064-0069
98-98-6
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342613-71-2
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$139.00/250mg
29681-43-4
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342613-71-2
48 suppliers
$139.00/250mg
19798-80-2
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$6.00/1g
342613-71-2
48 suppliers
$139.00/250mg